Arizona State Sun Devils vs Mississippi State Bulldogs Prediction, Picks and Game Preview - 09/06/2025

Game Time: 7:30 pm ET, Saturday, September 6, 2025

Venue:  Davis Wade Stadium, Mississippi State, MS

Where to Watch:  ESPN2

DraftKings:  Point Spread:  ASU -6.5, MS State +6.5; Over/Under:  58.5 points

Bet365:  Point Spread:  ASU -6.5, MS State +6.5; Over/Under:  59 points

BetMGM:  Point Spread:  ASU -6.5, MS State +6.5; Over/Under:  58.5 points

Arizona State Sun Devils:  1-0 (0-0) (8th place, Big 12)

Mississippi State Bulldogs:  1-0 (0-0) (11th place, SEC)

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Arizona State Sun Devils:  won their last game at home against the Northern Arizona Lumberjacks 38-19.

Mississippi State Bulldogs:  won their last game on the road against the Southern Miss Golden Eagles 34-17.

Arizona State is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Northern Arizona 38-19. Sam Leavitt was the starting QB and he completed 25/39 passes for 257 passing yards, 2 touchdowns, and 1 interception. Sam Leavitt led the team in rushing yards with 73 and 2 TDs. Jordyn Tyson led the receivers with 141 receiving yards on 12 receptions and 2 TDs. Jordan Crook led the defense in that game with 5 solo tackles and 2 assisted tackles while Jordan Crook, Keith Abney II, and Elijah O'Neal each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

Mississippi State is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 0-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Southern Miss 34-17. Blake Shapen was the starting QB and he completed 26/34 passes for 270 passing yards, 1 touchdown, and 1 interception. Davon Booth led the team in rushing yards with 79 and 1 TD. Brenen Thompson led the receivers with 92 receiving yards on 7 receptions. Jalen Smith led the defense in that game with 3 solo tackles and 4 assisted tackles while Will Whitson led the defense in sacks with 1. Brylan Lanier came away with the only interception for them in that one.

The current betting odds have Arizona State listed as a 6.5 point favorite in this game according to Draftkings Sportsbook. Arizona State is 1-0 overall and they didn't look great in their season opener. They beat Northern Arizona 38-19, but they struggled to pull away for a lot of that game. This is still the team that won the Big 12 Championship and had a good run in the CFP last season so they are going to be looking to have a better game here. Meanwhile, Mississippi State is 1-0 overall and they didn't look great in their season opener either. They were on the road against USM and won 34-17, but they also struggled to pull away in that game as it was pretty close at halftime. Now they are playing their home opener, but Arizona State beat them at home last season and even though the score was 30-23, it wasn't really a close game. Arizona State jumped out to a big lead last season and didn't need to do much in the 2nd half as Mississippi State had to fight their way back into the game. Mississippi State has improved a lot this season, but they are still going to be one of the worst teams in the SEC while Arizona State has a shot to win the Big 12 again. Arizona State is still the better team here and they will come prepared to pick up a good road win against an SEC opponent. The best way to place a bet here is on Arizona State to cover the spread in this game. 

Arizona State Mississippi State Prediction:  Our NCAAF Pick for Saturday, September 6, 2025 (7:30 pm ET start time) is ASU 34 MS State 20.

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Arizona State Sun Devils: 17-9 ATS in all lined games. 7-2 ATS as a favorite. 5-0 ATS as a favorite of 3.5 to 10 points. 4-0 ATS after a win by 17 or more points. 4-1 OVER as a favorite of 3.5 to 10 points. 4-1 OVER after scoring 37 points or more last game.

Mississippi State Bulldogs: 5-9 ATS in home lined games. 1-8 ATS as an underdog of 3.5 to 10 points. 11-4 OVER in home lined games. 6-1 OVER after playing their last game on the road.

Arizona State Sun Devils:  J. Moss (WR) Questionable - Foot. C. Dyer (QB) Questionable - Undisclosed.

Mississippi State Bulldogs:  None.

“Happy we got a W, and it’s always good to win ugly. That’s one of the best things about coaching is when you win ugly and it wakes people up a little bit. That’s great, this is good.” - Kenny Dillingham after his team’s win against NAU in their last game. 

"We're just in a completely different spot. Whether it's a couple of our pieces up front being able to be in the system, whether it's Zico, Seydou, Blake, we've got guys that have been in the system and are in year two to where they know exactly what we want." - Jeff Lebby on his team’s run game this season. 

WR McClain, Malik

WR Moss, Jalen

WR Tyson, Jordyn

WR Hamilton, Jaren

TE Metayer, Chamon

QB Leavitt, Sam

RB Brown, Kyson

WR Thompson, Brenen

WR Mosley, Jordan

WR Evans III, Anthony

TE Traore, Seydou

QB Shapen, Blake

RB Booth, Davon

Passing: S. Leavitt (257)

Rushing: K. Brown (73)

Receiving: J. Tyson (141)

Touchdowns: J. Tyson (2)

Passing: B. Shapen (270)

Rushing: D. Booth (79)

Receiving: B. Thompson (92)

Touchdowns: F. Bothwell (2)

Coaches:

Arizona State Sun Devils: Kenny Dillingham (3rd season)

Mississippi State Bulldogs: Jeff Lebby (2nd season)