Arizona Diamondbacks vs Washington Nationals Prediction, Preview and Odds - 07/25/2026

Game Time: 4:05 pm ET, Saturday, July 25, 2026

Venue:  Nationals Park, Washington, DC

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Diamondbacks +114, Nationals -137; Over/Under:  9 runs

Bet365:  Moneyline odds:  Diamondbacks +115, Nationals -135; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Diamondbacks +115, Nationals -140; Over/Under:  9 runs

Arizona Diamondbacks:  54-49 (2nd place, NL West)

Washington Nationals:  52-51 (4th place, NL East)

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Arizona Diamondbacks:  8-2 last 10

Washington Nationals:  5-5 last 10

The Diamondbacks are entering this series off a win and won their 1-off game against the St Louis Cardinals on Thursday. They enter this game with a 54-49 record overall and have a road record of 23-27. This is the 2nd game of a 3-game series with the Nationals on Saturday with the series opener still to be played on Friday. Their offense ranks 20th in the MLB with a .709 OPS. Eduardo Rodríguez is their starting pitcher on Friday while rookie pitcher Mitch Bratt is making his start in this game on Saturday. He is 0-0 with a 5.06 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 2 HR, and 1 BB with 4 SO on 8 hits through 4.2 IP against the Athletics.

The Nationals are entering this series off a win and won their 3-game series against the Colorado Rockies 2-1 in their last series. They enter this game with a 52-51 record overall and have a home record of 20-31. This is the 2nd game of a 3-game series with the Diamondbacks on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 2nd in the MLB with a .771 OPS. Carson Palmquist is their starting pitcher on Friday while Foster Griffin is making his start in this game on Saturday. He is 11-2 with a 2.68 ERA this season. His team won their last 6 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 1 walk with 2 strikeouts on 8 hits through 7 innings pitched against the Athletics.

The current betting odds have the Nationals listed as a favorite in this game according to Draftkings Sportsbook. The Diamondbacks have looked good in their games this season with their 54-49 record overall which has them right near the top of the NL West. They haven't been a good road team though with their 23-27 road record this year. Meanwhile, the Nationals have looked good in their games this season with their 52-51 record overall, but that record has them right near the bottom of the NL East. They have looked terrible in their own ballpark too with their 20-31 home record this season. The Diamondbacks have been rolling lately as they are 8-2 in their last 10 games and they have been putting up a ton of runs lately, but their offense hasn't looked great all season and their pitching has been up and down too. The Nationals are 5-5 in their last 10 games and they haven't looked great lately, but they have one of the best offenses in MLB at the moment and they also have the better pitching matchup. Griffin is on the mound for the Nationals in this one and he has looked great this season. He is 11-2 with a 2.68 ERA and he has been their best starter by far. He is coming off another great start in which he gave up 1 earned run, something that has been a common theme for him, and the team has had a ton of success with him too, winning 6 games in a row now with him starting. The Diamondbacks are going with Bratt in this one and he hasn't looked great this year. He is 0-0 with a 5.06 ERA and has had some trouble in his rookie season. He only gave up 2 earned runs in his last start and the team has won 2 of their last 3 games with him starting, but that hasn't been a common theme for him and he will give up runs with how hot this Nationals offense has been. The Nationals still have the edge offensively in this one, so look for them to take advantage of this pitching matchup. The best way to place a bet here is on the Nationals to win this game. 

Diamondbacks Nationals Prediction:  Our MLB Pick for Saturday, July 25, 2026 (4:05 pm ET start time) is Nationals 6 Diamondbacks 2.

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Arizona Diamondbacks: 104-107 (+9.9 units) on the moneyline in road games. 128-105 (+9.9 units) on the moneyline vs. an NL team with a team batting average of .255 or worse. 108-108 (+12.2 units) on the moneyline when playing against a team with a winning record. 4-1 OVER on the road vs. an NL starting pitcher whose ERA is 3.20 or better.

Washington Nationals: 91-124 (-21 units) on the moneyline in home games. 33-35 (-12.3 units) on the moneyline as a favorite of -110 or higher. 53-65 (-3.9 units) on the moneyline vs. NL teams allowing 4.5 or more runs/game on the season. 31-17 OVER in home games.

Arizona Diamondbacks:  D. Jameson (RP) Fifteen Day IL - Hip. K. Marte (2B) Day To Day - Back. L. Gurriel Jr. (LF) Ten Day IL - Adductor. T. Troy (LF) Ten Day IL - Shoulder. Z. Gallen (SP) Fifteen Day IL - Elbow. J. Lawlar (LF) Ten Day IL - Hamstring. M. Soroka (SP) Fifteen Day IL - Lower-Body. R. Nelson (SP) Sixty Day IL - Elbow. J. McCann (C) Ten Day IL - Quad. B. Walston (SP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. A. Puk (RP) Sixty Day IL - Elbow. C. Burnes (SP) Sixty Day IL - Elbow. J. Martinez (RP) Sixty Day IL - Elbow. A. Saalfrank (RP) Sixty Day IL - Shoulder.

Washington Nationals:  P. Poulin (RP) Fifteen Day IL - Flexor. D. Millas (C) Ten Day IL - Finger. J. Irvin (SP) Sixty Day IL - Shoulder. B. Lord (RP) Fifteen Day IL - Side. M. Parker (RP) Sixty Day IL - Elbow. R. Lovelady (RP) Sixty Day IL - Triceps. K. Waldichuk (SP) Sixty Day IL - Forearm. J. Gray (SP) Sixty Day IL - Elbow. D. Herz (SP) Sixty Day IL - Elbow. T. Williams (SP) Sixty Day IL - Elbow.

“Not easy to do what he did. He comes to the ballpark, he’s always preparing to play. I know that. But the lineup goes out the night before, and there’s a couple things he’s probably going to come here and work on. And all of the sudden transitions an hour before the ballgame starts and he’s going to be starting at first base. I think he’s got the right mindset. He’s always ready.” - Torey Lovullo on Tyler Locklear after his team’s win against the Cardinals in their game on Thursday.

“For whatever reason, this one felt like it was extremely important for us to come out with a win. We leaned on [Cavalli], and he answered for us.” - Blake Butera after his team’s win against the Rockies in their game on Wednesday.

Corbin Carroll (L) RF

Geraldo Perdomo (S) SS

Gabriel Moreno (R) C

Max Kepler (L) LF

Adrian Del Castillo (L) DH

Tim Tawa (R) 3B

Ildemaro Vargas (S) 2B

Tyler Locklear (R) 1B

Ryan Waldschmidt (R) CF

James Wood (L) RF

Luis García Jr. (L) 1B

José Tena (L) DH

CJ Abrams (L) SS

Dylan Crews (R) CF

Daylen Lile (L) LF

Keibert Ruiz (S) C

Jorbit Vivas (L) 3B

Nasim Nuñez (S) 2B

Batting Average:  Tyler Locklear (.385)

Hits:  Ketel Marte (102)

Home Runs:  Ketel Marte (18)

RBI:  Ketel Marte (59)

Stolen Bases:  Geraldo Perdomo (16)

Wins:  Michael Soroka (8)

Saves:  Paul Sewald (23)

ERA:  Brandyn Garcia (1.69)

Batting Average:  Abimelec Ortiz (.500)

Hits:  James Wood (107)

Home Runs:  James Wood (28)

RBI:  CJ Abrams (76)

Stolen Bases:  Nasim Nuñez (37)

Wins:  Foster Griffin (11)

Saves:  Clayton Beeter (8)

ERA:  Eddy Yean (0.00)

Managers:

Arizona Diamondbacks: Torey Lovullo (10th season)

Washington Nationals: Blake Butera (1st season)