Arizona Diamondbacks vs Milwaukee Brewers Prediction, Preview and Odds - 08/28/2025

Game Time: 2:10 pm ET, Thursday, August 28, 2025

Venue:  American Family Field, Milwaukee, WI 

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Diamondbacks +140, Brewers -172; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Diamondbacks +140, Brewers -170; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Diamondbacks +145, Brewers -175; Over/Under:  8.5 runs

Arizona Diamondbacks:  64-69 (4th place, NL West)

Milwaukee Brewers:  83-50 (1st place, NL Central)

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Arizona Diamondbacks:  4-6 last 10

Milwaukee Brewers:  5-5 last 10

The Diamondbacks are entering this series off a loss and won their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 64-69 record overall and have a road record of 30-37. This is the series finale of a 4-game series with the Brewers on Thursday with the 3rd game still to be played on Wednesday. The Diamondbacks lost the series opener on Monday and the 2nd game on Tuesday. Their offense ranks 4th in the MLB with a .763 OPS. Ryne Nelson is their starting pitcher on Wednesday while Nabil Crismatt is making his start in this game on Thursday. He is 1-0 with a 1.00 ERA this season. His team won their last game this season with him making an appearance. In his last MLB regular season appearance, he allowed 0 ER, 0 HR, and 3 BB with 4 SO on 4 hits through 4 IP against the Cincinnati Reds.

The Brewers are entering this series off a loss and lost their 3-game series against the San Francisco Giants 2-1 in their last series. They enter this game with an 83-50 record overall and have a home record of 45-22. This is the 4th game of a 4-game series with the Diamondbacks on Thursday with the 3rd game of this series still to be played on Wednesday. The Brewers won the 1st game of this series on Monday and the 2nd game on Tuesday. Their offense ranks 11th in the MLB with a .738 OPS. Quinn Priester is their starting pitcher on Wednesday while Jose Quintana is making his start in this game on Thursday. He is 10-4 with a 3.32 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 2 homers, and 2 walks with 2 strikeouts on 2 hits through 5.1 innings pitched against the San Francisco Giants.

The current betting odds have the Brewers listed as a favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 83-50 record overall which has them right at the top of the NL Central with the best record in the entire MLB. They have also looked great in their own ballpark with their 45-22 home record this year. Meanwhile, the Diamondbacks haven't looked great in their games this season with their 64-69 record overall which has them right in the middle of the NL West. They haven't been a great road team either with their 30-37 road record this season. The Diamondbacks haven't looked great lately either, going 4-6 in their last 10 games while the Brewers are 5-5, and the Brewers do have the more reliable starter in this one too. The Brewers are going with Quintana and he has been solid this season. He is 10-4 with a 3.32 ERA and the team has had a lot of success with him this year. He is coming off another good start in which he gave up 2 earned runs and the team has won 4 of their last 5 games with him starting too. The Diamondbacks are going with Crismatt in this one and he has also looked good this season. He is 1-0 with a 1.00 ERA, but he has only had 2 appearances this year. The team won his last appearance and he hasn't been giving up many runs either, but he isn't going to keep that up against this Brewers offense that has been rolling lately. The Brewers have the edge here with their more reliable starter at home. The best way to place a bet here is on the Brewers to win this game. 

Diamondbacks Brewers Prediction:  Our MLB Pick for Thursday, August 28, 2025 (2:10 pm ET start time) is Brewers 7 Diamondbacks 4.

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Arizona Diamondbacks: 53-42 (+7.5 units) on the moneyline against NL Central opponents. 122-116 (+17.2 units) on the moneyline in road games. 103-117 (+16 units) on the moneyline as an underdog of +100 or higher. 20-13 UNDER vs. teams outscoring opp by 0.5 or more runs/game on the season.

Milwaukee Brewers: 44-51 (-12.3 units) on the moneyline against NL West opponents. 80-69 (-8.4 units) on the moneyline vs. NL teams allowing 4.5 or more runs/game on the season. 52-35 (-12.8 units) on the moneyline as a favorite of -150 or more. 23-15 UNDER at home when the total is 8 to 8.5.

Arizona Diamondbacks:  A. DeSclafani (SP) Fifteen Day IL - Thumb. K. Ginkel (RP) Sixty Day IL - Shoulder. T. Henry (RP) Sixty Day IL - Elbow. R. Thompson (RP) Fifteen Day IL - Scapular Strain. C. Montes De Oca (RP) Sixty Day IL - Elbow. J. Martinez (RP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. C. Burnes (SP) Sixty Day IL - Elbow. A. Puk (RP) Sixty Day IL - Elbow. B. Walston (SP) Sixty Day IL - Elbow.

Milwaukee Brewers:  G. Anderson (RP) Fifteen Day IL - Ankle. J. Ortiz (SS) Ten Day IL - Hamstring. D. Hall (RP) Fifteen Day IL - Oblique. L. Henderson (SP) Fifteen Day IL - Elbow. J. Chourio (CF) Ten Day IL - Hamstring. J. Montgomery (SP) Sixty Day IL - Elbow. R. Hoskins (1B) Ten Day IL - Thumb. G. Mitchell (CF) Sixty Day IL - Oblique. R. Zastryzny (RP) Fifteen Day IL - Ribs. C. Thomas (SP) Sixty Day IL - Elbow. R. Gasser (SP) Sixty Day IL - Elbow.

“Blaze has definitely been growing up right before our very eyes. He was tooled up, had everything right in front of him, but I think at the end of the day to become a complete baseball player, there was some development that needed to take place more physically, as well as emotionally. He gets very revved up, and to slow the game down to be able to dissect what's happening and do his job, that's something that we've seen emerging a lot this year.” - Torey Lovullo on Blaze Alexander this season. 

“It feels like everything is finally clicking.” - Rookie pitcher Jacob Misiorowski after their win against the Diamondbacks in their game on Tuesday.

Geraldo Perdomo (S) SS

Ketel Marte (S) 2B

Corbin Carroll (L) RF

Lourdes Gurriel Jr. (R) DH

Pavin Smith (L) 1B

Gabriel Moreno (R) C

Jake McCarthy (L) LF

Blaze Alexander (R) 3B

Alek Thomas (L) CF

Brice Turang (L) 2B

William Contreras (R) C

Christian Yelich (L) DH

Andrew Vaughn (R) 1B

Sal Frelick (L) RF

Isaac Collins (S) LF

Anthony Seigler (L) 3B

Blake Perkins (S) CF

Andruw Monasterio (R) SS

Batting Average:  Josh Naylor (.292)

Hits:  Geraldo Perdomo (141)

Home Runs:  Corbin Carroll (27)

RBI:  Geraldo Perdomo (86)

Stolen Bases:  Geraldo Perdomo (23)

Wins:  Brandon Pfaadt (12)

Saves:  Shelby Miller (10)

ERA:  Christian Montes De Oca (0.00)

Batting Average:  Andrew Vaughn (.299)

Hits:  Brice Turang (136)

Home Runs:  Christian Yelich (26)

RBI:  Christian Yelich (90)

Stolen Bases:  Brice Turang (22)

Wins:  Freddy Peralta (15)

Saves:  Trevor Megill (30)

ERA:  Abner Uribe (1.71)

Managers:

Arizona Diamondbacks: Torey Lovullo (9th season)

Milwaukee Brewers: Pat Murphy (2nd season)