Arizona Diamondbacks vs Milwaukee Brewers Prediction, Preview and Odds - 08/27/2025

Game Time: 7:40 pm ET, Wednesday, August 27, 2025

Venue:  American Family Field, Milwaukee, WI 

Where to Watch:  DBACKS.tv, FDSWI

DraftKings:  Moneyline odds:  Diamondbacks +118, Brewers -144; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Diamondbacks +120, Brewers -140; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Diamondbacks +120, Brewers -140; Over/Under:  8.5 runs

Arizona Diamondbacks:  64-68 (3rd place, NL West)

Milwaukee Brewers:  82-50 (1st place, NL Central)

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Arizona Diamondbacks:  4-6 last 10

Milwaukee Brewers:  4-6 last 10

The Diamondbacks are entering this series off a loss and won their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 64-68 record overall and have a road record of 30-36. This is the 3rd game of a 4-game series with the Brewers on Wednesday with the 2nd game still to be played on Tuesday. The Diamondbacks lost the series opener on Monday. Their offense ranks 4th in the MLB with a .762 OPS. Brandon Pfaadt is their starting pitcher on Tuesday while Ryne Nelson is making his start in this game on Wednesday. He is 6-3 with a 3.63 ERA this season. His team lost 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 3 ER, 0 HR, and 2 BB with 6 SO on 4 hits through 6 IP against the Cincinnati Reds.

The Brewers are entering this series off a loss and lost their 3-game series against the San Francisco Giants 2-1 in their last series. They enter this game with an 82-50 record overall and have a home record of 44-22. This is the 3rd game of a 4-game series with the Diamondbacks on Wednesday with the 2nd game of this series still to be played on Tuesday. The Brewers won the 1st game of this series on Monday. Their offense ranks 11th in the MLB with a .736 OPS. Rookie pitcher Jacob Misiorowski is their starting pitcher on Tuesday while Quinn Priester is making his start in this game on Wednesday. He is 11-2 with a 3.44 ERA this season. His team won their last 15 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 5 walks with 4 strikeouts on 3 hits through 4.1 innings pitched against the Chicago Cubs.

The current betting odds have the Brewers listed as a favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 82-50 record overall which has them right at the top of the NL Central with the best record in the entire MLB. They have also looked great in their own ballpark with their 44-22 home record this year. Meanwhile, the Diamondbacks haven't looked great in their games this season with their 64-68 record overall which has them right in the middle of the NL West. They haven't been a great road team either with their 30-36 road record this season. Neither team has looked great lately as they are both 4-6 in their last 10 games, but the Brewers do have the egde at home with their starter. They are going with Priester in this one and he has looked great this season. He is 11-2 with a 3.44 ERA and the team has had a ton of success with him lately. He is coming off another great start in which he only gave up 1 earned run and the team has won 15 games in a row now with him starting. The Diamondbacks are going with Nelson in this one and he has also looked good this season. He is 6-3 with a 3.63 ERA, but the team hasn't had a ton of success with him lately. They have lost 4 of their last 5 games with him starting and he did give up 3 earned runs in his last start too. Priester gives the Brewers a big edge at home here, especially with the way their offense has been rolling. The best way to place a bet here is on the Brewers to win this game.

Diamondbacks Brewers Prediction:  Our MLB Pick for Wednesday, August 27, 2025 (7:40 pm ET start time) is Brewers 2 Diamondbacks 0.

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Arizona Diamondbacks: 53-41 (+8.5 units) on the moneyline against NL Central opponents. 122-115 (+18.2 units) on the moneyline in road games. 103-116 (+17 units) on the moneyline as an underdog of +100 or higher. 20-12 UNDER vs. teams outscoring opp by 0.5 or more runs/game on the season.

Milwaukee Brewers: 43-51 (-13.3 units) on the moneyline against NL West opponents. 79-69 (-9.4 units) on the moneyline vs. NL teams allowing 4.5 or more runs/game on the season. 23-14 UNDER at home when the total is 8 to 8.5.

Arizona Diamondbacks:  A. DeSclafani (SP) Fifteen Day IL - Thumb. K. Ginkel (RP) Sixty Day IL - Shoulder. T. Henry (RP) Sixty Day IL - Elbow. R. Thompson (RP) Fifteen Day IL - Scapular Strain. C. Montes De Oca (RP) Sixty Day IL - Elbow. J. Martinez (RP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. C. Burnes (SP) Sixty Day IL - Elbow. A. Puk (RP) Sixty Day IL - Elbow. B. Walston (SP) Sixty Day IL - Elbow.

Milwaukee Brewers:  G. Anderson (RP) Fifteen Day IL - Ankle. J. Ortiz (SS) Ten Day IL - Hamstring. D. Hall (RP) Fifteen Day IL - Oblique. L. Henderson (SP) Fifteen Day IL - Elbow. J. Chourio (CF) Ten Day IL - Hamstring. J. Montgomery (SP) Sixty Day IL - Elbow. R. Hoskins (1B) Ten Day IL - Thumb. G. Mitchell (CF) Sixty Day IL - Oblique. R. Zastryzny (RP) Fifteen Day IL - Ribs. C. Thomas (SP) Sixty Day IL - Elbow. R. Gasser (SP) Sixty Day IL - Elbow.

“It was a really, really tough day for us. You know, the loss [to the Reds], we had to absorb that, and then we had the five-or-six-hour delay, and everybody's had that in their lives. So we're not exempt from things that happen every single day to people that don't fly charter flights.” - Torey Lovullo after his team’s loss against the Brewers in their game on Monday.

“It was a good night. Way too many positives outweigh the outcome of the outing. Look, the main thing is we won the game, which is huge for us. The sixth inning, you just chalk that up to being a ‘baseball inning.’ I haven’t had one of those up until this point.” - Brandon Woodruff after their win against the Diamondbacks in their game on Monday.

Geraldo Perdomo (S) SS

Ketel Marte (S) 2B

Corbin Carroll (L) RF

Lourdes Gurriel Jr. (R) LF

Pavin Smith (L) 1B

Gabriel Moreno (R) C

Adrian Del Castillo (L) DH

Blaze Alexander (R) 3B

Alek Thomas (L) CF

Brice Turang (L) 2B

William Contreras (R) C

Christian Yelich (L) DH

Andrew Vaughn (R) 1B

Sal Frelick (L) RF

Caleb Durbin (R) 3B

Isaac Collins (S) LF

Blake Perkins (S) CF

Andruw Monasterio (R) SS

Batting Average:  Josh Naylor (.292)

Hits:  Geraldo Perdomo (139)

Home Runs:  Corbin Carroll (27)

RBI:  Geraldo Perdomo (84)

Stolen Bases:  Geraldo Perdomo (23)

Wins:  Brandon Pfaadt (12)

Saves:  Shelby Miller (10)

ERA:  Christian Montes De Oca (0.00)

Batting Average:  Andrew Vaughn (.298)

Hits:  Brice Turang (135)

Home Runs:  Christian Yelich (26)

RBI:  Christian Yelich (90)

Stolen Bases:  Brice Turang (22)

Wins:  Freddy Peralta (15)

Saves:  Trevor Megill (30)

ERA:  Abner Uribe (1.71)

Managers:

Arizona Diamondbacks: Torey Lovullo (9th season)

Milwaukee Brewers: Pat Murphy (2nd season)