Arizona Diamondbacks vs Milwaukee Brewers Prediction, Preview and Odds - 08/26/2025

Game Time: 7:40 pm ET, Tuesday, August 26, 2025

Venue:  American Family Field, Milwaukee, WI 

Where to Watch:  DBACKS.tv, FDSWI

DraftKings:  Moneyline odds:  Diamondbacks +128, Brewers -157; Over/Under:  8 runs

Bet365:  Moneyline odds:  Diamondbacks +130, Brewers -155; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Diamondbacks +130, Brewers -155; Over/Under:  8 runs

Arizona Diamondbacks:  64-67 (3rd place, NL West)

Milwaukee Brewers:  81-50 (1st place, NL Central)

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Arizona Diamondbacks:  5-5 last 10

Milwaukee Brewers:  4-6 last 10

The Diamondbacks are entering this series off a loss and won their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 64-67 record overall and have a road record of 30-35. This is the 2nd game of a 4-game series with the Brewers on Tuesday with the series opener still to be played on Monday. Their offense ranks 3rd in the MLB with a .764 OPS. Eduardo Rodríguez is their starting pitcher on Monday while Brandon Pfaadt is making his start in this game on Tuesday. He is 12-8 with a 4.95 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 ER, 0 HR, and 1 BB with 5 SO on 5 hits through 7 IP against the Cleveland Guardians.

The Brewers are entering this series off a loss and lost their 3-game series against the San Francisco Giants 2-1 in their last series. They enter this game with an 81-50 record overall and have a home record of 43-22. This is the 2nd game of a 4-game series with the Diamondbacks on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 11th in the MLB with a .736 OPS. Brandon Woodruff is their starting pitcher on Monday while rookie pitcher Jacob Misiorowski is making his start in this game on Tuesday. He is 4-2 with a 4.19 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 0 homers, and 3 walks with 5 strikeouts on 1 hit through 4 innings pitched against the Chicago Cubs.

The current betting odds have the Brewers listed as a favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 81-50 record overall which has them right at the top of the NL Central with the best record in the entire MLB. Meanwhile, the Diamondbacks haven't looked great in their games this season with their 64-67 record overall which has them right in the middle of the NL West. They haven't been a great road team either with their 30-35 road record this season. The Brewers haven't looked great lately as they are only 4-6 in their last 10 games and have cooled off a lot now from their long win streak, but they will be looking to bounce back at home after losing their series against the Giants there over the weekend. Misiorowski is on the mound for the Brewers in this one and he has looked good this season. He is 4-2 with a 4.19 ERA and he did go through a little rough patch after a really hot start to his career, but he has looked better in his starts lately. He has been giving up less runs again, giving up 3 earned runs in his last start, and the team has won 2 of their last 3 games with him starting too. The Diamondbacks are going with Pfaadt in this one and he has looked really up and down this season. He is 12-8 with a 4.95 ERA and has been giving up quite a few runs all season. The team has been having success with him lately, winning 3 of their last 4 games with him on the mound, and he also gave up just 2 earned runs in his last start too. That hasn't been a common theme for him this season though and the Brewers do have a really good offense to put up runs. The Diamondbacks also have a great offense this season, but the Brewers have the better pitching matchup with Misiorowski and that gives them the edge at home in a series they will be looking to bounce back in. The best way to place a bet here is on the Brewers to win this game. 

Diamondbacks Brewers Prediction:  Our MLB Pick for Tuesday, August 26, 2025 (7:40 pm ET start time) is Brewers 4 Diamondbacks 3.

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Arizona Diamondbacks: 53-40 (+9.5 units) on the moneyline against NL Central opponents. 122-114 (+19.2 units) on the moneyline in road games. 103-115 (+18 units) on the moneyline as an underdog of +100 or higher. 20-11 UNDER vs. teams outscoring opp by 0.5 or more runs/game on the season.

Milwaukee Brewers: 42-51 (-14.3 units) on the moneyline against NL West opponents. 50-35 (-14.9 units) on the moneyline as a favorite of -150 or more. 78-69 (-10.4 units) on the moneyline vs. NL teams allowing 4.5 or more runs/game on the season. 23-13 UNDER at home when the total is 8 to 8.5.

Arizona Diamondbacks:  A. DeSclafani (SP) Fifteen Day IL - Thumb. K. Ginkel (RP) Sixty Day IL - Shoulder. T. Henry (RP) Sixty Day IL - Elbow. R. Thompson (RP) Fifteen Day IL - Scapular Strain. C. Montes De Oca (RP) Sixty Day IL - Elbow. J. Martinez (RP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. C. Burnes (SP) Sixty Day IL - Elbow. A. Puk (RP) Sixty Day IL - Elbow. B. Walston (SP) Sixty Day IL - Elbow.

Milwaukee Brewers:  J. Ortiz (SS) Ten Day IL - Hamstring. D. Hall (RP) Fifteen Day IL - Oblique. L. Henderson (SP) Fifteen Day IL - Elbow. J. Chourio (CF) Ten Day IL - Hamstring. J. Montgomery (SP) Sixty Day IL - Elbow. R. Hoskins (1B) Ten Day IL - Thumb. G. Mitchell (CF) Sixty Day IL - Oblique. R. Zastryzny (RP) Fifteen Day IL - Ribs. C. Thomas (SP) Sixty Day IL - Elbow. R. Gasser (SP) Sixty Day IL - Elbow.

“We're not flying across the country to get our butts kicked. We're going across the country to play some baseball, and I'm looking forward to that.” - Torey Lovullo after his team’s loss against the Reds in their game on Sunday.

“God, I wish we could have got that for Ueck. What a great crowd, a great turnout to honor such an incredible man. I didn’t think there was any way that the baseball gods would bestow this on us.” - Pat Murphy after his team’s loss against the Giants in their game on Sunday.

Geraldo Perdomo (S) SS

Ketel Marte (S) 2B

Corbin Carroll (L) RF

Lourdes Gurriel Jr. (R) DH

Pavin Smith (L) 1B

Jake McCarthy (L) LF

Blaze Alexander (R) 3B

Alek Thomas (L) CF

James McCann (R) C

Sal Frelick (L) RF

Caleb Durbin (R) 3B

William Contreras (R) DH

Christian Yelich (L) LF

Andrew Vaughn (R) 1B

Brice Turang (L) 2B

Danny Jansen (R) C

Brandon Lockridge (R) CF

Andruw Monasterio (R) SS

Batting Average:  Josh Naylor (.292)

Hits:  Geraldo Perdomo (138)

Home Runs:  Corbin Carroll (27)

RBI:  Geraldo Perdomo (84)

Stolen Bases:  Geraldo Perdomo (23)

Wins:  Brandon Pfaadt (12)

Saves:  Shelby Miller (10)

ERA:  Christian Montes De Oca (0.00)

Batting Average:  Andrew Vaughn (.304)

Hits:  Brice Turang (134)

Home Runs:  Christian Yelich (26)

RBI:  Christian Yelich (88)

Stolen Bases:  Brice Turang (22)

Wins:  Freddy Peralta (15)

Saves:  Trevor Megill (30)

ERA:  Abner Uribe (1.73)

Managers:

Arizona Diamondbacks: Torey Lovullo (9th season)

Milwaukee Brewers: Pat Murphy (2nd season)