Arizona Diamondbacks vs Boston Red Sox Prediction, Preview and Odds - 08/19/2026

Game Time: 4:10 pm ET, Wednesday, August 19, 2026

Venue:  Fenway Park, Boston, MA 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Diamondbacks +123, Red Sox -149; Over/Under:  8 runs

Bet365:  Moneyline odds:  Diamondbacks +125, Red Sox -150; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Diamondbacks +125, Red Sox -150; Over/Under:  8.5 runs

Arizona Diamondbacks:  66-60 (3rd place, NL West)

Boston Red Sox:  67-58 (3rd place, AL East)

Do not miss out on our expert handicapper analysis! Matt Fargo is on a HOT STREAK in MLB on a 12-4 MLB RUN for +$12,370 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Arizona Diamondbacks:  5-5 last 10

Boston Red Sox:  3-7 last 10

The Diamondbacks are entering this series off a loss and won their 3-game series against the Atlanta Braves 2-1 in their last series. They enter this game with a 66-60 record overall and have a road record of 30-33. This is the series finale of a 3-game series with the Red Sox on Wednesday with the 2nd game still to be played on Tuesday. The Diamondbacks lost the series opener on Monday. Their offense ranks 19th in the MLB with a .712 OPS. Merrill Kelly is their starting pitcher on Tuesday while Brandon Pfaadt is making his start in this game on Wednesday. He is 7-1 with a 3.11 ERA this season. His team won 8 of their last 9 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 0 ER, 0 HR, and 0 BB with 7 SO on 2 hits through 7 IP against the Atlanta Braves.

The Red Sox are entering this series off a loss and lost their 3-game series against the Pittsburgh Pirates 2-1 in their last series. They enter this game with a 67-58 record overall and have a home record of 30-31. This is the 3rd game of a 3-game series with the Diamondbacks on Wednesday with the 2nd game of this series still to be played on Tuesday. The Red Sox won the 1st game of this series on Monday. Their offense ranks 14th in the MLB with a .724 OPS. Ranger Suarez is their starting pitcher on Tuesday while Payton Tolle is making his start in this game on Wednesday. He is 8-6 with a 2.97 ERA this season. His team won their last 7 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 2 walks with 4 strikeouts on 2 hits through 8 innings pitched against the Toronto Blue Jays.

The current betting odds have the Red Sox listed as a favorite in this game according to Draftkings Sportsbook. The Red Sox have looked good in their games this season with their 67-58 record overall which has them right in the middle of the AL East. They haven't looked great in their own ballpark though with their 30-31 home record this season. Meanwhile, the Diamondbacks have looked good in their games this season with their 66-60 record overall which has them right in the middle of the NL West. They haven't been a great road team though with their 30-33 road record this year. The Red Sox are 3-7 in their last 10 games and they haven't looked good lately, but they have been going through a slump after being one of the hottest teams in the league the last 2 months. The Diamondbacks haven't looked that great lately either, now 5-5 in their last 10 games, and they have been really up and down. The Diamondbacks are going with Pfaadt in this one and he has looked good this season. He is 7-1 with a 3.11 ERA and the team has been having a ton of success with him lately. They have won 8 of their last 9 games with him starting and he is coming off another great start in which he gave up no runs. The Red Sox are going with Tolle though and he has also looked great this season. He is 8-6 with a 2.97 ERA and his team has been having a ton of success with him too. They have won 7 games in a row now with him starting and he is coming off a great start in which he gave up no runs. Neither starter is going to give an inch in this game, so the bullpens could be a big factor here and the Red Sox have definitely had the more reliable pitching staff all season. Look for the Red Sox to get back on track at home in this series with better pitching giving them the edge here. The best way to place a bet here is on the Red Sox to win this game. 

Diamondbacks Red Sox Prediction:  Our MLB Pick for Wednesday, August 19, 2026 (4:10 pm ET start time) is Red Sox 2 Diamondbacks 1.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Arizona Diamondbacks Boston Red Sox prediction, be sure to drop by every day for our daily MLB projections and previews.

Arizona Diamondbacks: 234-216 (+7.9 units) on the moneyline in all games. 111-113 (+12.9 units) on the moneyline in road games. 96-110 (+15.3 units) on the moneyline as an underdog of +100 or higher. 9-3 UNDER vs. an AL starting pitcher whose WHIP is 1.300 or better.

Boston Red Sox: 18-22 (-6.5 units) on the moneyline against NL West opponents. 115-107 (-21.9 units) on the moneyline in home games. 143-114 (-15.1 units) on the moneyline as a favorite of -110 or higher. 16-10 UNDER vs. a starting pitcher who gives up 0.5 or less HR's/start.

Arizona Diamondbacks:  N. Arenado (3B) Day To Day - Neck. R. Thompson (RP) Fifteen Day IL - Back. D. Jameson (RP) Fifteen Day IL - Hip. Z. Gallen (SP) Sixty Day IL - Elbow. L. Gurriel Jr. (LF) Ten Day IL - Adductor. T. Troy (LF) Ten Day IL - Shoulder. R. Nelson (SP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. B. Walston (SP) Sixty Day IL - Elbow. C. Burnes (SP) Sixty Day IL - Elbow. A. Puk (RP) Sixty Day IL - Elbow. A. Saalfrank (RP) Sixty Day IL - Shoulder.

Boston Red Sox:  J. Jones (DH) Day To Day - Undisclosed. J. Slaten (RP) Fifteen Day IL - Elbow. M. Yoshida (DH) Ten Day IL - Hamstring. G. Whitlock (RP) Fifteen Day IL - Elbow. I. Kiner-Falefa (2B) Sixty Day IL - Forearm. C. Mead (3B) Ten Day IL - Hand. Z. Kelly (RP) Sixty Day IL - Elbow. R. Anthony (LF) Sixty Day IL - Wrist. G. Crochet (SP) Sixty Day IL - Shoulder. T. Story (SS) Sixty Day IL - Abdomen. K. Crawford (SP) Sixty Day IL - Wrist. T. Casas (1B) Sixty Day IL - Knee. J. Oviedo (SP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Elbow.

"It's been a crazy day. All I know is that he's dealing with a personal issue. We're trying to figure that out, and he didn't show up today and he was put on the restricted list. That's as much as I know right now. I just was doing my best to reach out to him, and there was very little coming back." - Torey Lovullo on Ketel Marte after his team’s loss against the Red Sox in their game on Monday. 

“It's been great. I think obviously it was well documented how the beginning of the year went for him, the frustrations and that he believes he's a starter. We still think that. But he's in a really good place as far as accepting the role and knowing that he's not only accepting the role, but he's going out there and helping us win in that role, and that's a good place for him to be.” - Chad Tracy after his team’s win against the Diamondbacks in their game on Monday. 

Ildemaro Vargas (S) 2B

Corbin Carroll (L) RF

Gabriel Moreno (R) C

Geraldo Perdomo (S) SS

Jordan Lawlar (R) CF

Tim Tawa (R) 1B

Jose Fernandez (R) 3B

Lars Nootbaar (L) DH

Ryan Waldschmidt (R) LF

Nick Sogard (S) 2B

Ceddanne Rafaela (R) CF

Wilyer Abreu (L) RF

Willson Contreras (R) 1B

Adley Rutschman (S) C

Caleb Durbin (R) 3B

Andruw Monasterio (R) SS

Mickey Gasper (S) DH

Eli White (R) LF

Batting Average:  Gabriel Moreno (.307)

Hits:  Ketel Marte (117)

Home Runs:  Ketel Marte (21)

RBI:  Ketel Marte (67)

Stolen Bases:  Corbin Carroll (17)

Wins:  Eduardo Rodriguez (12)

Saves:  Paul Sewald (24)

ERA:  Dennis Santana (0.00)

Batting Average:  Jake Rogers (.500)

Hits:  Ceddanne Rafaela (136)

Home Runs:  Willson Contreras (25)

RBI:  Willson Contreras (73)

Stolen Bases:  Jarren Duran (17)

Wins:  Sonny Gray (15)

Saves:  Aroldis Chapman (27)

ERA:  Erik Miller (0.00)

Managers:

Arizona Diamondbacks: Torey Lovullo (10th season)

Boston Red Sox: Chad Tracy (Interim)