Arizona Cardinals vs New Orleans Saints Prediction, Preview and Odds - 09/07/2025

Game Time: 1:00 pm ET, Sunday, September 7, 2025

Venue:  Caesars Superdome, New Orleans, LA

Where to Watch:  CBS

DraftKings:  Point Spread:  Cardinals -6.5, Saints +6.5; Over/Under:  42.5 points

Bet365:  Point Spread:  Cardinals -6.5, Saints +6.5; Over/Under:  42.5 points

BetMGM:  Point Spread:  Cardinals -6.5, Saints +6.5; Over/Under:  42.5 points

Arizona Cardinals:  0-0 (NFC West)

New Orleans Saints:  0-0 (NFC South)

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Arizona Cardinals:  N/A

New Orleans Saints:  N/A

The Cardinals finished last season with an 8-9 record overall and they were 3-3 in their division games too. They had a 6-3 record in their home games and had a 2-6 record in their road games where they will be in this game. Last season, their offense was averaging 23.5 points per game and their defense was allowing an average of 22.3 points per game. Their offense was also averaging 358.2 yards per game and their defense was allowing an average of 342.5 yards per game. Kyler Murray led the team in passing yards with 3,851, James Conner led the team in rushing yards with 1,094, and Trey McBride led the team in receiving yards with 1,146.

The Saints finished last season with a 5-12 record overall and they were 2-4 in their division games too. They had a 3-6 record in their home games and had a 2-6 record in their road games where they will be in this game. Last season, their offense was averaging 19.9 points per game and their defense was allowing an average of 23.4 points per game. Their offense was also averaging 320.1 yards per game and their defense was allowing an average of 379.9 yards per game. Derek Carr led the team in passing yards with 2,145, Alvin Kamara led the team in rushing yards with 950, and Juwan Johnson led the team in receiving yards with 548.

The current betting odds have the Cardinals listed as a 6.5 point favorite in this game according to Draftkings Sportsbook. The Cardinals didn't have a great season last year, finishing 8-9 overall and missing the playoffs again. They are now in the 3rd season with Gannon as head coach and they will be looking to take a big step this year with a playoff appearance, Kyler Murray didn't have a great season, but there is plenty of talent around him this year and they shouldn't have any problems against this Saints defense that wasn't great last season. The Saints went 5-12 last season and were one of the worst teams in the NFL. They had a lot of issues at QB, and those aren't going to change this year. They have named Spencer Rattler the starting QB and he wasn't great last season in his few starts. They don't have many better options though and they are projected to be one of the worst teams in the NFL this season once again. They had one of the worst offenses in the league last year and even with the weapons they have, they aren't going to have a great offense with Rattler leading the way. This Cardinals defense should also be more improved this season so it's not going to be easy for them to move the ball here, and the Cardinals do have the talent on offense to bury them on the scoreboard. The Cardinals are in desperate need of a statement game to start the season too. The best way to place a bet here is on the Cardinals to cover the spread in this game. 

Cardinals Saints Prediction:  Our NFL Pick for Sunday, September 7, 2025 (1:00 pm ET start time) is Cardinals 34 Saints 13.

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Arizona Cardinals: 18-24 ATS as a road favorite of 7 points or less. 9-16 ATS on the road against NFC South division opponents. 29-18 OVER against NFC South division opponents. 

New Orleans Saints: 72-53 ATS as an underdog of 3.5 to 9.5 points. 15-9 ATS at home against NFC West division opponents. 29-19 OVER against NFC West division opponents. 39-27 OVER as a home underdog of 7 points or less.

Arizona Cardinals:  None.

New Orleans Saints:  None.

“Health is always first with all of our guys. We've got a couple guys nicked up. So we'll just see kinda how it all falls together.” - Jonathan Gannon on the team’s injuries coming into this new NFL season. 

"He's just been consistent. He's made some really good decisions throughout the whole entire process and his ability to make plays with his arm and his feet have certainly showed up." - Kellen Moore on naming Spencer Rattler the starting QB.

WR Harrison Jr., Marvin

WR Wilson, Michael 

WR Jones, Zay

TE McBride, Trey

QB Murray, Kyler

RB Conner, James

WR Olave, Chris

WR Shaheed, Rashid

WR Vele, Devaughn

TE Johnson, Juwan

QB Rattler, Spencer

RB Kamara, Alvin

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Coaches:

Arizona Cardinals: Jonathan Gannon (3rd season)

New Orleans Saints: Kellen Moore (1st season)