Alabama Crimson Tide vs South Carolina Gamecocks Prediction, Picks and Game Preview - 10/25/2025

Game Time: 3:30 pm ET, Saturday, October 25, 2025

Venue:  Williams-Brice Stadium, Columbia, SC

Where to Watch:  ABC

DraftKings:  Point Spread:  Alabama -13.5, South Carolina +13.5; Over/Under:  47.5 points

Bet365:  Point Spread:  Alabama -13.5, South Carolina +13.5; Over/Under:  47.5 points

BetMGM:  Point Spread:  Alabama -13.5, South Carolina +13.5; Over/Under:  47.5 points

Alabama Crimson Tide:  6-1 (4-0) (2nd place, SEC)

South Carolina Gamecocks:  3-4 (1-4) (12th place, SEC)

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Alabama Crimson Tide:  won their last game at home against the Tennessee Volunteers 37-20.

South Carolina Gamecocks:  lost their last game at home against the Oklahoma Sooners 26-7.

Alabama is entering this game with a 6-1 record overall and they have a 4-0 record in their conference games too. They are 4-0 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Tennessee 37-20. Ty Simpson was the starting QB and he completed 19/29 passes for 253 passing yards, 2 touchdowns, and 0 interceptions. Germie Bernard led the team in rushing yards with 49. Ryan Williams led the receivers with 87 receiving yards on 5 receptions. Yhonzae Pierre led the defense in that game with 5 solo tackles and 1 assisted tackle while Yhonzae Pierre led the defense in sacks with 3. Zabien Brown came away with the only interception for them in that one.

 

 

 

South Carolina is entering this game with a 3-4 record overall and they have a 1-4 record in their conference games too. They are 2-2 in their home games, 0-2 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Oklahoma 26-7. LaNorris Sellers was the starting QB and he completed 17/25 passes for 124 passing yards, 1 touchdown, and 0 interceptions. Rahsul Faison led the team in rushing yards with 50. Jayden Sellers led the receivers with 57 receiving yards on 6 receptions. Judge Collier led the defense in that game with 10 solo tackles and 0 assisted tackles while Bryan Thomas Jr. led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Alabama listed as a 13.5 point favorite in this game according to Draftkings Sportsbook. Alabama has looked great in their games this season with their 6-1 record overall and their 4-0 conference record which has them right near the top of the SEC. They lost their first game of the season to Florida State, but they have won 6 games in a row now and they look like a completely different team. They are ranked inside the top 25, but they are starting to round themselves into one of the best teams in the SEC in a year where it didn't look like there was going to be a clear answer. They are off a 37-20 win over Tennessee in their last one and their offense has been looking better and better in each game. Meanwhile, South Carolina hasn't looked good in their games this season with their 3-4 record overall and their 1-4 conference record which has them right near the bottom of the SEC. They were ranked inside the top 25 to start the season, but they have looked terrible with some bad losses. They are off a 26-7 loss at home to Oklahoma in their last one and their offense hasn't been able to do much in their games. Sellers hasn't looked like the player he was supposed to be, and the defense hasn't looked as good as it was advertised either. South Carolina hasn't been able to hold their own against better opponents in the SEC and Alabama is rolling right now as they are clearly trying to make a statement that they haven't gone anywhere as the SEC power just yet. The best way to place a bet here is on Alabama to cover the spread in this game. 

Alabama South Carolina Prediction:  Our NCAAF Pick for Saturday, October 25, 2025 (3:30 pm ET start time) is Alabama 42 South Carolina 10.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Alabama Crimson Tide South Carolina Gamecocks prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

Alabama Crimson Tide: 21-13 ATS in all lined games. 14-7 ATS against conference opponents. 8-4 ATS after a win by 17 or more points. 9-2 OVER when the total is between 42.5 and 49. 8-3 OVER after scoring 37 points or more last game. 

South Carolina Gamecocks: 4-8 ATS when playing against a top-level team (Win Pct. > 75%). 2-7 ATS versus good defensive teams - allowing 310 yards/game or less. 8-3 OVER off a loss against a conference rival. 

Alabama Crimson Tide:  Q. Russaw (LB) Questionable - Leg. D. Meadows (WR) Questionable - Undisclosed. J. Latham (LB) Questionable - Neck. C. Jones (LB) Questionable - Undisclosed. J. Mbakwe (WR) Questionable - Undisclosed. D. Lewis Jr. (TE) Questionable - Undisclosed. J. Beaman (DL) Out - Lower Body.

South Carolina Gamecocks:  D. Stewart (DL) Questionable - Undisclosed. B. Rowe Jr. (WR) Questionable - Undisclosed. D. Miles (DL) Questionable - Undisclosed. C. Henry (OG) Questionable - Undisclosed. N. Hay (OG) Questionable - Undisclosed. J. Shivers (OG) Questionable - Undisclosed.

“The biggest thing for our guys is how committed to the process they are. You can see it. You can hear it. Pads are popping every day in practice. They have an edge to them still and haven’t lost it.” - Kalen DeBoer after his team’s win against Tennessee in their last game. 

“Right now, I am not getting the most out of this team as the head football coach.” - Shane Beamer after his team’s loss against Oklahoma in their last game. 

WR Horton, Isaiah

WR Bernard, Germie

WR Williams, Ryan

TE Lewis Jr., Danny

TE Cuevas, Josh

QB Simpson, Ty

RB Miller, Jam

WR Harbor, Nyck

WR Jacobs, Vandrevius

WR Rowe Jr., Brian

TE Hunt, Brady

QB Sellers, LaNorris

RB Faison, Rahsul

Passing: Ty Simpson (1,931)

Rushing: Jam Miller (282)

Receiving: Germie Bernard (472)

Touchdowns: Germie Bernard (6)

Passing: LaNorris Sellers (1,134)

Rushing: Rahsul Faison (281)

Receiving: Vandrevius Jacobs (343)

Touchdowns: Rahsul Faison (3)

Coaches:

Alabama Crimson Tide: Kalen DeBoer (2nd season)

South Carolina Gamecocks: Shane Beamer (5th season)