Alabama Crimson Tide vs Missouri Tigers Prediction, Picks and Game Preview - 10/11/2025

Game Time: 12:00 pm ET, Saturday, October 11, 2025

Venue:  Faurot Field at Memorial Stadium, Columbia, MO

Where to Watch:  ABC

DraftKings:  Point Spread:  Alabama -3, Mizzou +3; Over/Under:  52.5 points

Bet365:  Point Spread:  Alabama -3, Mizzou +3; Over/Under:  52.5 points

BetMGM:  Point Spread:  Alabama -3, Mizzou +3; Over/Under:  53.5 points

Alabama Crimson Tide:  4-1 (2-0) (5th place, SEC)

Missouri Tigers:  5-0 (1-0) (3rd place, SEC)

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Alabama Crimson Tide:  won their last game at home against the Vanderbilt Commodores 30-14.

Missouri Tigers:  won their last game at home against the UMass Minutemen 42-6.

Alabama is entering this game with a 4-1 record overall and they have a 2-0 record in their conference games too. They are 3-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Vanderbilt 30-14. Ty Simpson was the starting QB and he completed 23/31 passes for 340 passing yards, 2 touchdowns, and 1 interception. Jamarion Miller led the team in rushing yards with 136 and 1 TD. Ryan Williams led the receivers with 98 receiving yards on 6 receptions and 1 TD. Justin Jefferson led the defense in that game with 9 solo tackles and 5 assisted tackles while Justin Jefferson led the defense in sacks with 1. Keon Sabb came away with the only interception for them in that one.

 

 

 

Missouri is entering this game with a 5-0 record overall and they have a 1-0 record in their conference games too. They are 5-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against UMass 42-6. Beau Pribula was the starting QB and he completed 26/29 passes for 241 passing yards, 1 touchdown, and 1 interception. Ahmad Hardy led the team in rushing yards with 130 and 3 TDs. Kevin Coleman Jr. led the receivers with 108 receiving yards on 12 receptions. Nick DeLoach Jr. led the defense in that game with 2 solo tackles and 0 assisted tackles while Darris Smith led the defense in sacks with 1. Santana Banner came away with the only interception for them in that one.

The current betting odds have Alabama listed as a 3 point favorite in this game according to Draftkings Sportsbook. Alabama has looked really good in their games this season with their 4-1 record overall and their 2-0 conference record which has them right near the top of the SEC again. They had a really rough start to the season with a road loss against Florida State, but they have bounced back nicely with 4 wins in a row now. They also have some good wins in the SEC like their road win over Georgia and they have been tested with 2 road games already so this Alabama team is starting to round themselves into the team they were supposed to be. Meanwhile, Missouri has looked great in their games this season with their 5-0 record overall and their 1-0 conference record which has them right near the top of the SEC. Missouri has a really good team this year and their offense has been rolling in their games, but their defense hasn't looked great at times and they haven't really been tested too much either. They started the season with a really weak schedule, their only conference win coming against a struggling South Carolina team, and they have also played all 5 of their games at home. They are going to be at home again here, but they have not truly been tested in any way other than a rivalry game against Kansas, and they had to work their way out of a big hole to start the game in that one. Alabama is starting to roll now with momentum on their side and they are going to show that they are still a true contender in the SEC. The best way to place a bet here is on Alabama to cover the spread in this game. 

Alabama Missouri Prediction:  Our NCAAF Pick for Saturday, October 11, 2025 (12:00 pm ET start time) is Alabama 31 Missouri 24.

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Alabama Crimson Tide: 20-12 ATS in all lined games. 13-6 ATS against conference opponents. 10-2 ATS when playing against a top-level team (Win Pct. > 75%). 24-17 UNDER after 3 or more consecutive wins against the spread. 52-31 UNDER versus good rushing teams - averaging 200  rushing yards/game or more.

Missouri Tigers: 19-28 ATS off a home blowout win by 28 points or more. 23-29 ATS at home vs. good teams - outscoring opponents by 10+ PPG on the season. 8-4 UNDER after a win by 17 or more points. 6-3 UNDER after allowing 14 points or less last game. 6-2 UNDER vs. good passing teams averaging 8 or more passing yards/att.

Alabama Crimson Tide:  Q. Russaw (LB) Questionable - Leg. J. Latham (LB) Questionable - Neck. J. Beaman (DL) Out - Lower Body.

Missouri Tigers:  C. Green (OG) Questionable - Undisclosed. L. Reichert (OG) Questionable - Undisclosed. S. Horn (QB) Out - Leg. B. Craig (K) Out - Undisclosed.

“I thought we played hard-nosed. The momentum we’re continuing to gain, there’s a confidence between offense and defense that the other side will come through when it matters most.” - Kalen DeBoer after his team’s win against Vandy in their last game. 

“It’s good to be undefeated with things to improve. I think that’s kind of the mentality of our coaching staff and our players. During the bye week, we’ve got to sharpen our edge. We cannot get complacent, so having things to work on is a positive.” - Eli Drinkwitz after his team’s win against UMass in their last game. 

WR Horton, Isaiah

WR Bernard, Germie

WR Williams, Ryan

TE Lewis Jr., Danny

TE Cuevas, Josh

QB Simpson, Ty

RB Miller, Jam

WR Johnson, Marquis

WR Manning, Joshua

WR Coleman Jr., Kevin

TE Norfleet, Brett

QB Pribula, Beau

RB Hardy, Ahmad

Passing: Ty Simpson (1,478)

Rushing: Jam Miller (182)

Receiving: Germie Bernard (392)

Touchdowns: Germie Bernard (6)

Passing: Beau Pribula (1,203)

Rushing: Ahmad Hardy (730)

Receiving: Kevin Coleman Jr. (386)

Touchdowns: Ahmad Hardy (9)

Coaches:

Alabama Crimson Tide: Kalen DeBoer (2nd season)

Missouri Tigers: Eli Drinkwitz (6th season)